Focal segmental glomerulosclerosis associated with cutaneous and systemic plasmacytosis

Alendronate-associated focal segmental glomerulosclerosis

Alendronate-associated focal segmental glomerulosclerosis Sir, Alendronate sodium, a bisphosphonate and commonly used pharmacologic agent for postmenopausal osteoporosis, has been rarely linked to renal toxicity [1] but not in association with focal segmental glomerulosclerosis (FSGS). A 55-year-old Caucasian woman developed proteinuria and hypertension. Nine years earlier, she had been diagnos...

Focal segmental glomerulosclerosis associated with pulmonary sarcoidosis.

Focal segmental glomerulosclerosis associated with mitochondrial disease

Primary mitochondrial diseases (MD) are complex, heterogeneous inherited diseases caused by mutations in either the mitochondrial or nuclear DNA. Glomerular diseases in MD have been reported with tRNA mutation m.3243A>G causing a syndrome of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). We describe here a case of focal segmental glomerulosclerosis (FSGS) ass...

Cutaneous and Systemic Plasmacytosis Associated with Renal Amyloidosis.

Cutaneous and systemic plasmacytosis (CSP) is a rare disorder of unknown etiology characterized by cutaneous polyclonal plasma cell infiltrates associated with various extracutaneous involvement and polyclonal hypergammaglobulinemia. Here, we report on a 54-year-old male patient with chronic renal insufficiency who presented with disseminated reddish-brown macules and plaques on the face and tr...

Focal Segmental Glomerulosclerosis.

Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness to immunosuppressive therapy and a risk of recurrence after kidney transplant-important disease characteristics. In contrast, adaptive FSGS is associated with excessive nephron workload due to increased body size, reduced nephron ...